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1993
15 years 8 months ago
Identification of Localized and Distributed Bottlenecks in Metabolic Pathways
The usual thermodynamicevaluation, based solely on the Standard Gibbs Energyof reaction, does not take into account the permissible ranges of concentrations of metabolites, and it...
Michael L. Mavrovouniotis
ECCB
2008
IEEE
15 years 6 months ago
Temporal logic patterns for querying dynamic models of cellular interaction networks
Abstract: Models of the dynamics of cellular interaction networks have become increasingly larger in recent years. Formal verification based on model checking provides a powerful t...
Pedro T. Monteiro, Delphine Ropers, Radu Mateescu,...
PSB
2010
15 years 4 months ago
Synthesis of Pharmacokinetic Pathways through Knowledge Acquisition and Automated Reasoning
teness of the knowledge bases, our approach also obtains facts through automated extraction from Medline abstracts. An essential component of our approach is to apply logical reaso...
Luis Tari, Saadat Anwar, Shanshan Liang, Jörg...
BMCBI
2008
114views more  BMCBI 2008»
15 years 6 months ago
Identifying a few foot-and-mouth disease virus signature nucleotide strings for computational genotyping
Background: Serotypes of the Foot-and-Mouth disease viruses (FMDVs) were generally determined by biological experiments. The computational genotyping is not well studied even with...
Guohui Lin, Zhipeng Cai, Junfeng Wu, Xiu-Feng Wan,...
BMCBI
2006
122views more  BMCBI 2006»
15 years 6 months ago
Computational reconstruction of transcriptional regulatory modules of the yeast cell cycle
Background: A transcriptional regulatory module (TRM) is a set of genes that is regulated by a common set of transcription factors (TFs). By organizing the genome into TRMs, a liv...
Wei-Sheng Wu, Wen-Hsiung Li, Bor-Sen Chen