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BMCBI
2006
116views more  BMCBI 2006»
15 years 6 months ago
Cluster analysis for DNA methylation profiles having a detection threshold
Background: DNA methylation, a molecular feature used to investigate tumor heterogeneity, can be measured on many genomic regions using the MethyLight technology. Due to the combi...
Paul Marjoram, Jing Chang, Peter W. Laird, Kimberl...
BMCBI
2007
148views more  BMCBI 2007»
15 years 6 months ago
Blast sampling for structural and functional analyses
Background: The post-genomic era is characterised by a torrent of biological information flooding the public databases. As a direct consequence, similarity searches starting with ...
Anne Friedrich, Raymond Ripp, Nicolas Garnier, Emm...
BMCBI
2007
153views more  BMCBI 2007»
15 years 6 months ago
Lower bounds on multiple sequence alignment using exact 3-way alignment
Background: Multiple sequence alignment is fundamental. Exponential growth in computation time appears to be inevitable when an optimal alignment is required for many sequences. E...
Charles J. Colbourn, Sudhir Kumar
BMCBI
2007
139views more  BMCBI 2007»
15 years 6 months ago
Significance analysis of microarray transcript levels in time series experiments
Background: Microarray time series studies are essential to understand the dynamics of molecular events. In order to limit the analysis to those genes that change expression over ...
Barbara Di Camillo, Gianna Toffolo, Sreekumaran K....
IOR
2008
128views more  IOR 2008»
15 years 6 months ago
Promised Lead-Time Contracts Under Asymmetric Information
We study the important problem of how a supplier should optimally share the consequences of demand uncertainty (i.e., the cost of inventory excesses and shortages) with a retailer...
Holly Lutze, Özalp Özer