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BMCBI
2008
124views more  BMCBI 2008»
15 years 7 months ago
A relation based measure of semantic similarity for Gene Ontology annotations
Background: Various measures of semantic similarity of terms in bio-ontologies such as the Gene Ontology (GO) have been used to compare gene products. Such measures of similarity ...
Brendan Sheehan, Aaron J. Quigley, Benoit Gaudin, ...
BMCBI
2006
165views more  BMCBI 2006»
15 years 6 months ago
Validation and functional annotation of expression-based clusters based on gene ontology
Background: The biological interpretation of large-scale gene expression data is one of the paramount challenges in current bioinformatics. In particular, placing the results in t...
Ralf Steuer, Peter Humburg, Joachim Selbig
BMCBI
2006
97views more  BMCBI 2006»
15 years 6 months ago
Goulphar: rapid access and expertise for standard two-color microarray normalization methods
Background: Raw data normalization is a critical step in microarray data analysis because it directly affects data interpretation. Most of the normalization methods currently used...
Sophie Lemoine, Florence Combes, Nicolas Servant, ...
JCB
2006
185views more  JCB 2006»
15 years 6 months ago
A Probabilistic Methodology for Integrating Knowledge and Experiments on Biological Networks
Biological systems are traditionally studied by focusing on a specific subsystem, building an intuitive model for it, and refining the model using results from carefully designed ...
Irit Gat-Viks, Amos Tanay, Daniela Raijman, Ron Sh...
BMCBI
2004
96views more  BMCBI 2004»
15 years 6 months ago
A hybrid clustering approach to recognition of protein families in 114 microbial genomes
Background: Grouping proteins into sequence-based clusters is a fundamental step in many bioinformatic analyses (e.g., homology-based prediction of structure or function). Standar...
Timothy J. Harlow, J. Peter Gogarten, Mark A. Raga...