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BMCBI
2010
84views more  BMCBI 2010»
15 years 6 months ago
Testing the additional predictive value of high-dimensional molecular data
Background: While high-dimensional molecular data such as microarray gene expression data have been used for disease outcome prediction or diagnosis purposes for about ten years i...
Anne-Laure Boulesteix, Torsten Hothorn
BMCBI
2007
104views more  BMCBI 2007»
15 years 6 months ago
Joint mapping of genes and conditions via multidimensional unfolding analysis
Background: Microarray compendia profile the expression of genes in a number of experimental conditions. Such data compendia are useful not only to group genes and conditions base...
Katrijn Van Deun, Kathleen Marchal, Willem J. Heis...
BMCBI
2008
155views more  BMCBI 2008»
15 years 6 months ago
ComPath: comparative enzyme analysis and annotation in pathway/subsystem contexts
Background: Once a new genome is sequenced, one of the important questions is to determine the presence and absence of biological pathways. Analysis of biological pathways in a ge...
Kwangmin Choi, Sun Kim
BMCBI
2007
99views more  BMCBI 2007»
15 years 6 months ago
Flexible mapping of homology onto structure with Homolmapper
Background: Over the past decade, a number of tools have emerged for the examination of homology relationships among protein sequences in a structural context. Most recent softwar...
Nathan C. Rockwell, J. Clark Lagarias
BMCBI
2010
190views more  BMCBI 2010»
15 years 6 months ago
Sample size and statistical power considerations in high-dimensionality data settings: a comparative study of classification alg
Background: Data generated using `omics' technologies are characterized by high dimensionality, where the number of features measured per subject vastly exceeds the number of...
Yu Guo, Armin Graber, Robert N. McBurney, Raji Bal...