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157
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BMCBI
2010
15 years 6 months ago
2010
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
148
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BMCBI
2010
15 years 6 months ago
2010
Background: Estimation of DNA duplex hybridization free energy is widely used for predicting cross-hybridizations in DNA computing and microarray experiments. A number of software...
223
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BMCBI
2010
15 years 6 months ago
2010
Background: Several diseases, many of which nowadays pandemic, consist of multifactorial pathologies. Paradigmatic examples come from the immune response to pathogens, in which ca...
197
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BMCBI
2010
15 years 6 months ago
2010
Background: Biological networks offer us a new way to investigate the interactions among different components and address the biological system as a whole. In this paper, a revers...
140
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BMCBI
2010
15 years 6 months ago
2010
Background: Thermophilic proteins sustain themselves and function at higher temperatures. Despite their structural and functional similarities with their mesophilic homologues, th...