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BMCBI
2010
105views more  BMCBI 2010»
15 years 6 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
TC
2011
15 years 1 months ago
Performing Arithmetic Operations on Round-to-Nearest Representations
—During any composite computation, there is a constant need for rounding intermediate results before they can participate in further processing. Recently, a class of number repre...
Peter Kornerup, Jean-Michel Muller, Adrien Panhale...
CVPR
2007
IEEE
16 years 8 months ago
Implicit Active Contours Driven by Local Binary Fitting Energy
In this paper, we propose a novel region-based active contour model for image segmentation with a variational level set formulation. By introducing a local binary fitting energy, ...
Chunming Li, Chiu-Yen Kao, John C. Gore, Zhaohua D...
WWW
2010
ACM
16 years 1 months ago
Tracking the random surfer: empirically measured teleportation parameters in PageRank
PageRank computes the importance of each node in a directed graph under a random surfer model governed by a teleportation parameter. Commonly denoted alpha, this parameter models ...
David F. Gleich, Paul G. Constantine, Abraham D. F...
FOCS
2008
IEEE
16 years 27 days ago
Shallow-Low-Light Trees, and Tight Lower Bounds for Euclidean Spanners
We show that for every n-point metric space M and positive integer k, there exists a spanning tree T with unweighted diameter O(k) and weight w(T) = O(k · n1/k ) · w(MST(M)), an...
Yefim Dinitz, Michael Elkin, Shay Solomon