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AB
2007
Springer
15 years 10 months ago
Efficient Haplotype Inference with Pseudo-boolean Optimization
Abstract. Haplotype inference from genotype data is a key computational problem in bioinformatics, since retrieving directly haplotype information from DNA samples is not feasible ...
Ana Graça, João Marques-Silva, In&ec...
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
15 years 10 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee
CIBCB
2006
IEEE
15 years 10 months ago
Efficient Probe Selection in Microarray Design
Abstract-- The DNA microarray technology, originally developed to measure the level of gene expression, had become one of the most widely used tools in genomic study. Microarrays h...
Leszek Gasieniec, Cindy Y. Li, Paul Sant, Prudence...
RECOMB
2010
Springer
15 years 8 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
ISMB
1996
15 years 8 months ago
A Knowledge-Based Method for Protein Structure Refinement and Prediction
The native conformation of a protein, in a given environment, is determined entirely by the various interatomic interactions dictated by the amino acid sequence (1-3). We describe...
Shankar Subramaniam, David K. Tcheng, James M. Fen...
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