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BIOINFORMATICS
2005
151views more  BIOINFORMATICS 2005»
15 years 6 months ago
Differential and trajectory methods for time course gene expression data
Motivation: The issue of high dimensionality in microarray data has been, and remains, a hot topic in statistical and computational analysis. Efficient gene filtering and differen...
Yulan Liang, Bamidele Tayo, Xueya Cai, Arpad Kelem...
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BIOINFORMATICS
2005
93views more  BIOINFORMATICS 2005»
15 years 6 months ago
Donuts, scratches and blanks: robust model-based segmentation of microarray images
Inner holes, artifacts and blank spots are common in microarray images, but current image analysis methods do not pay them enough attention. We propose a new robust model-based me...
Qunhua Li, Chris Fraley, Roger Eugene Bumgarner, K...
BIOINFORMATICS
2005
152views more  BIOINFORMATICS 2005»
15 years 6 months ago
Intervention in context-sensitive probabilistic Boolean networks
Motivation: Intervention in a gene regulatory network is used to help it avoid undesirable states, such as those associated with a disease. Several types of intervention have been...
Ranadip Pal, Aniruddha Datta, Michael L. Bittner, ...
BIOINFORMATICS
2005
72views more  BIOINFORMATICS 2005»
15 years 6 months ago
Use of within-array replicate spots for assessing differential expression in microarray experiments
Motivation. Spotted arrays are often printed with probes in duplicate or triplicate, but current methods for assessing differential expression are not able to make full use of the...
Gordon K. Smyth, Joëlle Michaud, Hamish S. Sc...
BMCBI
2005
72views more  BMCBI 2005»
15 years 6 months ago
Shortest triplet clustering: reconstructing large phylogenies using representative sets
Background: Understanding the evolutionary relationships among species based on their genetic information is one of the primary objectives in phylogenetic analysis. Reconstructing...
Le Sy Vinh, Arndt von Haeseler