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BIOINFORMATICS
2006
118views more  BIOINFORMATICS 2006»
15 years 6 months ago
A probabilistic dynamical model for quantitative inference of the regulatory mechanism of transcription
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Magnus Rattray, Neil D. Lawrenc...
BIOINFORMATICS
2006
92views more  BIOINFORMATICS 2006»
15 years 6 months ago
What should be expected from feature selection in small-sample settings
Motivation: High-throughput technologies for rapid measurement of vast numbers of biological variables offer the potential for highly discriminatory diagnosis and prognosis; howev...
Chao Sima, Edward R. Dougherty
BIOINFORMATICS
2006
124views more  BIOINFORMATICS 2006»
15 years 6 months ago
Probabilistic inference of transcription factor concentrations and gene-specific regulatory activities
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Neil D. Lawrence, Magnus Rattra...
BIOINFORMATICS
2004
119views more  BIOINFORMATICS 2004»
15 years 6 months ago
Analysis of variance components in gene expression data
Motivation: A microarray experiment is a multi-step process, and each step is a potential source of variation. There are two major sources of variation: biological variation and t...
James J. Chen, Robert R. Delongchamp, Chen-An Tsai...
CSB
2004
IEEE
112views Bioinformatics» more  CSB 2004»
15 years 10 months ago
Reasoning about Molecular Similarity and Properties
Ascertaining the similarity amongst molecules is a fundamental problem in biology and drug discovery. Since similar molecules tend to have similar biological properties, the notio...
Rahul Singh