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BMCBI
2006
139views more  BMCBI 2006»
15 years 6 months ago
Improvement in accuracy of multiple sequence alignment using novel group-to-group sequence alignment algorithm with piecewise li
Background: Multiple sequence alignment (MSA) is a useful tool in bioinformatics. Although many MSA algorithms have been developed, there is still room for improvement in accuracy...
Shinsuke Yamada, Osamu Gotoh, Hayato Yamana
BMCBI
2006
87views more  BMCBI 2006»
15 years 6 months ago
Phylogeny based discovery of regulatory elements
Background: Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites;...
Jason Gertz, Justin C. Fay, Barak A. Cohen
BMCBI
2006
156views more  BMCBI 2006»
15 years 6 months ago
Detecting the limits of regulatory element conservation and divergence estimation using pairwise and multiple alignments
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
Daniel A. Pollard, Alan M. Moses, Venky N. Iyer, M...
BMCBI
2006
150views more  BMCBI 2006»
15 years 6 months ago
Cluster analysis of protein array results via similarity of Gene Ontology annotation
Background: With the advent of high-throughput proteomic experiments such as arrays of purified proteins comes the need to analyse sets of proteins as an ensemble, as opposed to t...
Cheryl Wolting, C. Jane McGlade, David Tritchler
BMCBI
2007
126views more  BMCBI 2007»
15 years 6 months ago
Multiple non-collinear TF-map alignments of promoter regions
Background: The analysis of the promoter sequence of genes with similar expression patterns is a basic tool to annotate common regulatory elements. Multiple sequence alignments ar...
Enrique Blanco, Roderic Guigó, Xavier Messe...