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BMCBI
2010
113views more  BMCBI 2010»
15 years 6 months ago
Use of historic metabolic biotransformation data as a means of anticipating metabolic sites using MetaPrint2D and Bioclipse
Background: Predicting metabolic sites is important in the drug discovery process to aid in rapid compound optimisation. No interactive tool exists and most of the useful tools ar...
Lars Carlsson, Ola Spjuth, Samuel Adams, Robert C....
BMCBI
2007
105views more  BMCBI 2007»
15 years 6 months ago
Generating confidence intervals on biological networks
Background: In the analysis of networks we frequently require the statistical significance of some network statistic, such as measures of similarity for the properties of interact...
Thomas Thorne, Michael P. H. Stumpf
BMCBI
2007
128views more  BMCBI 2007»
15 years 6 months ago
Compression-based classification of biological sequences and structures via the Universal Similarity Metric: experimental assess
Background: Similarity of sequences is a key mathematical notion for Classification and Phylogenetic studies in Biology. It is currently primarily handled using alignments. Howeve...
Paolo Ferragina, Raffaele Giancarlo, Valentina Gre...
BMCBI
2008
122views more  BMCBI 2008»
15 years 6 months ago
ESLpred2: improved method for predicting subcellular localization of eukaryotic proteins
Background: The expansion of raw protein sequence databases in the post genomic era and availability of fresh annotated sequences for major localizations particularly motivated us...
Aarti Garg, Gajendra P. S. Raghava
BMCBI
2008
68views more  BMCBI 2008»
15 years 6 months ago
NullHap - a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles
Background: Laboratory techniques used to determine haplotypes are often too expensive for large-scale studies and lack of phase information is commonly overcome using likelihood-...
Robert M. Nowak, Rafal Ploski