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BMCBI
2011
15 years 1 months ago
RAIphy: Phylogenetic classification of metagenomics samples using iterative refinement of relative abundance index profiles
Background: Computational analysis of metagenomes requires the taxonomical assignment of the genome contigs assembled from DNA reads of environmental samples. Because of the diver...
Ozkan U. Nalbantoglu, Samuel F. Way, Steven H. Hin...
BMCBI
2011
15 years 1 months ago
A novel approach to the clustering of microarray data via nonparametric density estimation
Background: Cluster analysis is a crucial tool in several biological and medical studies dealing with microarray data. Such studies pose challenging statistical problems due to di...
Riccardo De Bin, Davide Risso
BMCBI
2011
15 years 1 months ago
A quality metric for homology modeling: the H-factor
Background: The analysis of protein structures provides fundamental insight into most biochemical functions and consequently into the cause and possible treatment of diseases. As ...
Eric di Luccio, Patrice Koehl
BMCBI
2011
15 years 1 months ago
Estimating developmental states of tumors and normal tissues using a linear time-ordered model
Background: Tumor cells are considered to have an aberrant cell state, and some evidence indicates different development states appearing in the tumorigenesis. Embryonic developme...
Bo Zhang, Beibei Chen, Tao Wu, Zhenyu Xuan, Xiaope...
BMCBI
2011
15 years 1 months ago
Simulated evolution applied to study the genetic code optimality using a model of codon reassignments
Background: As the canonical code is not universal, different theories about its origin and organization have appeared. The optimization or level of adaptation of the canonical ge...
Jose Santos, Ángel Monteagudo
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