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BMCBI
2011
15 years 1 months ago
nocoRNAc: Characterization of non-coding RNAs in prokaryotes
Background: The interest in non-coding RNAs (ncRNAs) constantly rose during the past few years because of the wide spectrum of biological processes in which they are involved. Thi...
Alexander Herbig, Kay Nieselt
BMCBI
2011
15 years 1 months ago
Dr. PIAS: an integrative system for assessing the druggability of protein-protein interactions
Background: The amount of data on protein-protein interactions (PPIs) available in public databases and in the literature has rapidly expanded in recent years. PPI data can provid...
Nobuyoshi Sugaya, Toshio Furuya
BMCBI
2011
15 years 1 months ago
DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning
Background: Accurate identification of protein domain boundaries is useful for protein structure determination and prediction. However, predicting protein domain boundaries from a...
Jesse Eickholt, Xin Deng, Jianlin Cheng
BMCBI
2011
15 years 1 months ago
Removing Noise From Pyrosequenced Amplicons
Background: In many environmental genomics applications a homologous region of DNA from a diverse sample is first amplified by PCR and then sequenced. The next generation sequenci...
Christopher Quince, Anders Lanzén, Russell ...
BMCBI
2011
15 years 1 months ago
Accurate statistics for local sequence alignment with position-dependent scoring by rare-event sampling
Background: Molecular database search tools need statistical models to assess the significance for the resulting hits. In the classical approach one asks the question how probable...
Stefan Wolfsheimer, Inke Herms, Sven Rahmann, Alex...
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