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BMCBI
2008
84views more  BMCBI 2008»
15 years 7 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
CORR
2010
Springer
249views Education» more  CORR 2010»
15 years 7 months ago
Lower Bounds on Near Neighbor Search via Metric Expansion
In this paper we show how the complexity of performing nearest neighbor (NNS) search on a metric space is related to the expansion of the metric space. Given a metric space we loo...
Rina Panigrahy, Kunal Talwar, Udi Wieder
JMLR
2008
150views more  JMLR 2008»
15 years 6 months ago
Discriminative Learning of Max-Sum Classifiers
The max-sum classifier predicts n-tuple of labels from n-tuple of observable variables by maximizing a sum of quality functions defined over neighbouring pairs of labels and obser...
Vojtech Franc, Bogdan Savchynskyy
NAR
2011
253views Computer Vision» more  NAR 2011»
14 years 9 months ago
tRNADB-CE 2011: tRNA gene database curated manually by experts
We updated the tRNADB-CE by analyzing 939 complete and 1301 draft genomes of prokaryotes and eukaryotes, 171 complete virus genomes, 121 complete chloroplast genomes and approxima...
Takashi Abe, Toshimichi Ikemura, Junichi Sugahara,...
ICDT
2009
ACM
147views Database» more  ICDT 2009»
16 years 7 months ago
The average-case complexity of counting distinct elements
We continue the study of approximating the number of distinct elements in a data stream of length n to within a (1? ) factor. It is known that if the stream may consist of arbitra...
David P. Woodruff