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BMCBI
2010
105views more  BMCBI 2010»
15 years 7 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
103views more  BMCBI 2010»
15 years 7 months ago
Predicting the protein-protein interactions using primary structures with predicted protein surface
Background: Many biological functions involve various protein-protein interactions (PPIs). Elucidating such interactions is crucial for understanding general principles of cellula...
Darby Tien-Hao Chang, Yu-Tang Syu, Po-Chang Lin
BMCBI
2010
147views more  BMCBI 2010»
15 years 7 months ago
Learning biological network using mutual information and conditional independence
Background: Biological networks offer us a new way to investigate the interactions among different components and address the biological system as a whole. In this paper, a revers...
Dong-Chul Kim, Xiaoyu Wang, Chin-Rang Yang, Jean G...
BMCBI
2007
162views more  BMCBI 2007»
15 years 7 months ago
Bioclipse: an open source workbench for chemo- and bioinformatics
Background: There is a need for software applications that provide users with a complete and extensible toolkit for chemo- and bioinformatics accessible from a single workbench. C...
Ola Spjuth, Tobias Helmus, Egon L. Willighagen, St...
BMCBI
2008
188views more  BMCBI 2008»
15 years 7 months ago
anNET: a tool for network-embedded thermodynamic analysis of quantitative metabolome data
Background: Compared to other omics techniques, quantitative metabolomics is still at its infancy. Complex sample preparation and analytical procedures render exact quantification...
Nicola Zamboni, Anne Kümmel, Matthias Heinema...
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