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BMCBI
2010
190views more  BMCBI 2010»
15 years 7 months ago
APIS: accurate prediction of hot spots in protein interfaces by combining protrusion index with solvent accessibility
Background: It is well known that most of the binding free energy of protein interaction is contributed by a few key hot spot residues. These residues are crucial for understandin...
Jun-Feng Xia, Xing-Ming Zhao, Jiangning Song, De-S...
BMCBI
2008
129views more  BMCBI 2008»
15 years 6 months ago
A unified approach to false discovery rate estimation
Background: False discovery rate (FDR) methods play an important role in analyzing highdimensional data. There are two types of FDR, tail area-based FDR and local FDR, as well as ...
Korbinian Strimmer
BMCBI
2008
166views more  BMCBI 2008»
15 years 6 months ago
Learning transcriptional regulatory networks from high throughput gene expression data using continuous three-way mutual informa
Background: Probability based statistical learning methods such as mutual information and Bayesian networks have emerged as a major category of tools for reverse engineering mecha...
Weijun Luo, Kurt D. Hankenson, Peter J. Woolf
BMCBI
2006
148views more  BMCBI 2006»
15 years 6 months ago
Predicting Class II MHC-Peptide binding: a kernel based approach using similarity scores
Background: Modelling the interaction between potentially antigenic peptides and Major Histocompatibility Complex (MHC) molecules is a key step in identifying potential T-cell epi...
Jesper Salomon, Darren R. Flower
ESWA
2007
176views more  ESWA 2007»
15 years 6 months ago
Credit scoring with a data mining approach based on support vector machines
The credit card industry has been growing rapidly recently, and thus huge numbers of consumers’ credit data are collected by the credit department of the bank. The credit scorin...
Cheng-Lung Huang, Mu-Chen Chen, Chieh-Jen Wang