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BMCBI
2008
130views more  BMCBI 2008»
15 years 7 months ago
A novel series of compositionally biased substitution matrices for comparing Plasmodium proteins
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
Kevin Brick, Elisabetta Pizzi
BMCBI
2010
121views more  BMCBI 2010»
15 years 7 months ago
MS4 - Multi-Scale Selector of Sequence Signatures: An alignment-free method for classification of biological sequences
Background: While multiple alignment is the first step of usual classification schemes for biological sequences, alignment-free methods are being increasingly used as alternatives...
Eduardo Corel, Florian Pitschi, Ivan Laprevotte, G...
BMCBI
2007
117views more  BMCBI 2007»
15 years 7 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BIOINFORMATICS
2006
95views more  BIOINFORMATICS 2006»
15 years 6 months ago
Family specific rates of protein evolution
: Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of euka...
Hannes Luz, Martin Vingron
DCG
2006
63views more  DCG 2006»
15 years 6 months ago
Common Tangents to Spheres in R3
We prove that four spheres in R3 have infinitely many real common tangents if and only if they have aligned centers and at least one real common tangent.
Ciprian Borcea, Xavier Goaoc, Sylvain Lazard, Sylv...