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BMCBI
2008
117views more  BMCBI 2008»
15 years 6 months ago
A probabilistic framework to predict protein function from interaction data integrated with semantic knowledge
Background: The functional characterization of newly discovered proteins has been a challenge in the post-genomic era. Protein-protein interactions provide insights into the funct...
Young-Rae Cho, Lei Shi, Murali Ramanathan, Aidong ...
BMCBI
2008
84views more  BMCBI 2008»
15 years 6 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2008
160views more  BMCBI 2008»
15 years 6 months ago
Predicting cancer involvement of genes from heterogeneous data
Background: Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characte...
Ramon Aragues, Chris Sander, Baldo Oliva
JCB
2007
144views more  JCB 2007»
15 years 6 months ago
Statistical Estimation of Statistical Mechanical Models: Helix-Coil Theory and Peptide Helicity Prediction
Analysis of biopolymer sequences and structures generally adopts one of two approaches: use of detailed biophysical theoretical models of the system with experimentally-determined...
Scott C. Schmidler, Joseph E. Lucas, Terrence G. O...
HPCA
2005
IEEE
16 years 6 months ago
Predicting Inter-Thread Cache Contention on a Chip Multi-Processor Architecture
This paper studies the impact of L2 cache sharing on threads that simultaneously share the cache, on a Chip Multi-Processor (CMP) architecture. Cache sharing impacts threads non-u...
Dhruba Chandra, Fei Guo, Seongbeom Kim, Yan Solihi...