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BMCBI
2010
150views more  BMCBI 2010»
15 years 6 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BMCBI
2010
97views more  BMCBI 2010»
15 years 6 months ago
Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach
Background: For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on es...
Dirk Repsilber, Sabine Kern, Anna Telaar, Gerhard ...
BMCBI
2010
113views more  BMCBI 2010»
15 years 6 months ago
A classification model for distinguishing copy number variants from cancer-related alterations
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...
Irina Ostrovnaya, Gouri Nanjangud, Adam B. Olshen
BMCBI
2010
122views more  BMCBI 2010»
15 years 6 months ago
An overview of the CellML API and its implementation
Background: CellML is an XML based language for representing mathematical models, in a machine-independent form which is suitable for their exchange between different authors, and...
Andrew K. Miller, Justin Marsh, Adam Reeve, Alan G...
BMCBI
2010
93views more  BMCBI 2010»
15 years 6 months ago
HAT: Hypergeometric Analysis of Tiling-arrays with application to promoter-GeneChip data
Background: Tiling-arrays are applicable to multiple types of biological research questions. Due to its advantages (high sensitivity, resolution, unbiased), the technology is ofte...
Erdogan Taskesen, Renee Beekman, Jeroen de Ridder,...
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