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BMCBI
2008
159views more  BMCBI 2008»
15 years 6 months ago
Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via log
Background: Growing interest on biological pathways has called for new statistical methods for modeling and testing a genetic pathway effect on a health outcome. The fact that gen...
Dawei Liu, Debashis Ghosh, Xihong Lin
BMCBI
2008
118views more  BMCBI 2008»
15 years 6 months ago
Virtual screening of GPCRs: An in silico chemogenomics approach
The G-protein coupled receptor (GPCR) superfamily is currently the largest class of therapeutic targets. In silico prediction of interactions between GPCRs and small molecules is ...
Laurent Jacob, Brice Hoffmann, Véronique St...
ALMOB
2006
138views more  ALMOB 2006»
15 years 6 months ago
A combinatorial optimization approach for diverse motif finding applications
Background: Discovering approximately repeated patterns, or motifs, in biological sequences is an important and widely-studied problem in computational molecular biology. Most fre...
Elena Zaslavsky, Mona Singh
ALMOB
2006
155views more  ALMOB 2006»
15 years 6 months ago
Refining motifs by improving information content scores using neighborhood profile search
The main goal of the motif finding problem is to detect novel, over-represented unknown signals in a set of sequences (e.g. transcription factor binding sites in a genome). The mo...
Chandan K. Reddy, Yao-Chung Weng, Hsiao-Dong Chian...
ENTCS
2008
137views more  ENTCS 2008»
15 years 6 months ago
Computerizing Mathematical Text with MathLang
Mathematical texts can be computerized in many ways that capture differing amounts of the mathematical meaning. At one end, there is document imaging, which captures the arrangeme...
Fairouz Kamareddine, J. B. Wells