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BMCBI
2010
105views more  BMCBI 2010»
15 years 6 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2008
155views more  BMCBI 2008»
15 years 6 months ago
Prediction of regulatory elements in mammalian genomes using chromatin signatures
Background: Recent genomic scale survey of epigenetic states in the mammalian genomes has shown that promoters and enhancers are correlated with distinct chromatin signatures, pro...
Kyoung-Jae Won, Iouri Chepelev, Bing Ren, Wei Wang
BMCBI
2008
118views more  BMCBI 2008»
15 years 6 months ago
Evaluation of phylogenetic footprint discovery for predicting bacterial cis-regulatory elements and revealing their evolution
Background: The detection of conserved motifs in promoters of orthologous genes (phylogenetic footprints) has become a common strategy to predict cis-acting regulatory elements. S...
Rekin's Janky, Jacques van Helden
BMCBI
2008
138views more  BMCBI 2008»
15 years 6 months ago
Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represent...
Ching-Wai Tan, David T. Jones
DSD
2007
IEEE
151views Hardware» more  DSD 2007»
15 years 10 months ago
P-Ware: A precise and scalable component-based simulation tool for embedded multiprocessor industrial applications
We present a component-based framework and its supporting simulation tool for joint software-hardware modelling and performance analysis of multiprocessor embedded systems. This j...
Ismail Assayad, Sergio Yovine